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Background
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Fas is a 45 kDa type I transmembrane protein belonging to the TNF receptor family. Fas contains 3 cysteine-rich repeats in the extracellular portion and a cytoplasmic motif called the `death domain' (DD). Death signals are triggered upon binding to its trimeric ligand FasL which induces oligomerization of Fas. The DD associates with FADD, which in turn connects to aspartate-specific proteases (caspases) that are implicated as mediators of most types of apoptotic cell death. Synonyms: APO-1, CD95, TNFRSF 6
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