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產品詳情

  • 產品名稱：Ac-TVASSSTAOctapeptidePeptide

  • 產品型號：
  • 產品廠商：Mol-Innov
  • 產品文檔：
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簡單介紹：
Ac-TVASSSTAOctapeptidePeptide
詳情介紹：
Characteristics Ac-TVASSSTA is an Octapeptide mimic of the N-terminal residues of the reactive center loop of PAI-1 (cf. P14-P7 residues). The Octapeptide inactivates PAI-1 by substituting for strand 4 in beta-sheet A in a manner that competes with formation of the latent species. Insertion of the peptide into beta-sheet A effectively forms a stable complex that converts PAI-1 into a substrate for tissue-type plasminogen activator (tPA) and other target proteinases. The resulting species of PAI-1 is thermodynamically stable and is useful for investigating the role of reactive center loop insertion.
Purification Chromatographically purified
Purity > 95?% by HPLC
Target Type Amino Acid
Restrictions For Research Use only
Format Lyophilized
Buffer Salt free
Handling Advice Supplied as a lyophilized powder. Add deionized water to original volume, aliquot and freeze unused portion.
Storage -80 °C
Product cited in: Li, Gorlatova, Lawrence, Schwartz: "Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands." in: The Journal of biological chemistry, Vol. 283, Issue 26, pp. 18147-57, 2008 (PubMed).

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