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  • 產(chǎn)品名稱:anti-InsulinReceptorbeta(ISR-beta)(pTyr1355)antibody

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anti-InsulinReceptorbeta(ISR-beta)(pTyr1355)antibody
詳情介紹:
Immunogen A phospho specific peptide corresponding to residues surrounding Y1355 of human Insulin Receptor beta
Isotype IgG
Purification Antigen affinity purification
Alternative Name Insulin Receptor beta (ISR-beta Antibody Abstract)
Background Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).
Synonyms: INSR, HHF5, CD220,
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid freeze / thaw cycles.
Storage -20 °C/-80 °C
Storage Comment Store at -20°C (regular) and -80°C (long term).
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